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MED-10 | Statin Use and Breast Cancer Survival: A Nationwide Cohort Study from Finland | Recent studies have suggested that statins, an established drug group in the prevention of cardiovascular mortality, could delay or prevent breast cancer recurrence but the effect on disease-specific mortality remains unclear. We evaluated risk of breast cancer death among statin users in a population-based cohort of b... |
MED-14 | Statin use after diagnosis of breast cancer and survival: a population-based cohort study. | BACKGROUND: Preclinical studies have shown that statins, particularly simvastatin, can prevent growth in breast cancer cell lines and animal models. We investigated whether statins used after breast cancer diagnosis reduced the risk of breast cancer-specific, or all-cause, mortality in a large cohort of breast cancer p... |
MED-118 | Alkylphenols in human milk and their relations to dietary habits in central Taiwan. | The aims of this study were to determine the concentrations of 4-nonylphenol (NP) and 4-octylphenol (OP) in 59 human milk samples and to examine related factors including mothers' demographics and dietary habits. Women who consumed over the median amount of cooking oil had significantly higher OP concentrations (0.98 n... |
MED-301 | Methylmercury: A Potential Environmental Risk Factor Contributing to Epileptogenesis | Epilepsy or seizure disorder is one of the most common neurological diseases in humans. Although genetic mutations in ion channels and receptors and some other risk factors such as brain injury are linked to epileptogenesis, the underlying cause for the majority of epilepsy cases remains unknown. Gene-environment inter... |
MED-306 | Sensitivity of Continuous Performance Test (CPT) at Age 14 Years to Developmental Methylmercury Exposure | Hit Reaction Time latencies (HRT) in the Continuous Performance Test (CPT) measure the speed of visual information processing. The latencies may involve different neuropsychological functions depending on the time from test initiation, i.e., first orientation, learning and habituation, then cognitive processing and foc... |
MED-329 | Phosphate is a vascular toxin. | Elevated phosphate (P) levels are seen in advanced renal failure and, together with dysregulated calcium, parathyroid hormone and vitamin D levels, contribute to the complex of chronic kidney disease-mineral and bone disease (CKD-MBD). Converging evidence from in vitro, clinical and epidemiological studies suggest that... |
MED-330 | Dietary Phosphorus Acutely Impairs Endothelial Function | Excessive dietary phosphorus may increase cardiovascular risk in healthy individuals as well as in patients with chronic kidney disease, but the mechanisms underlying this risk are not completely understood. To determine whether postprandial hyperphosphatemia may promote endothelial dysfunction, we investigated the acu... |
MED-332 | Public health impact of dietary phosphorus excess on bone and cardiovascular health in the general population. | This review explores the potential adverse impact of the increasing phosphorus content in the American diet on renal, cardiovascular, and bone health of the general population. Increasingly, studies show that phosphorus intakes in excess of the nutrient needs of a healthy population may significantly disrupt the hormon... |
MED-334 | Differences among total and in vitro digestible phosphorus content of plant foods and beverages. | OBJECTIVE: Among plant foods, grain products, legumes, and seeds are important sources of phosphorus (P). Current data on P content and absorbability of P from these foods are lacking. Measurement of in vitro digestible P (DP) content of foods may reflect absorbability of P. The objective of this study was to measure b... |
MED-335 | Differences among total and in vitro digestible phosphorus content of meat and milk products. | OBJECTIVE: Meat and milk products are important sources of dietary phosphorus (P) and protein. The use of P additives is common both in processed cheese and meat products. Measurement of in vitro digestible phosphorus (DP) content of foods may reflect absorbability of P. The objective of this study was to measure both ... |
MED-398 | The grapefruit: an old wine in a new glass? Metabolic and cardiovascular perspectives | Summary Grapefruit is a popular, tasty and nutritive fruit enjoyed globally. Biomedical evidence in the last 10 years has, however, shown that consumption of grapefruit or its juice is associated with drug interactions, which, in some cases, have been fatal. Grapefruit-induced drug interactions are unique in that the c... |
MED-557 | Dysmenorrhea. | Dysmenorrhea is the leading cause of recurrent short-term school absence in adolescent girls and a common problem in women of reproductive age. Risk factors for dysmenorrhea include nulliparity, heavy menstrual flow, smoking, and depression. Empiric therapy can be initiated based on a typical history of painful menses ... |
MED-666 | Is there a role for surgery in the treatment of mastalgia? | Breast pain is a common condition affecting most women at some stage in their reproductive life. Mastalgia is resistant to treatment in 6% of cyclical and 26% non-cyclical patients. Surgery is not widely used to treat this condition and only considered in patients with severe mastalgia resistant to medication. The aims... |
MED-691 | Ginger in the prevention of nausea and vomiting: a review. | Nausea and vomiting are physiological processes experienced by every human being at some stage of their life. They are complex protective mechanisms and the symptoms are influenced by the emetogenic response and stimuli. However, when these symptoms recur frequently, they can significantly reduce the quality of life an... |
MED-692 | The effectiveness and safety of ginger for pregnancy-induced nausea and vomiting: a systematic review. | BACKGROUND: Ginger has been used throughout the world as a therapeutic agent for centuries. The herb is increasingly used in Western society also, with one of the most common indications being pregnancy-induced nausea and vomiting (PNV). OBJECTIVES: To examine the evidence for the safety and effectiveness of ginger for... |
MED-702 | The efficacy and safety of liraglutide. | AIM OF THE REVIEW: To systematically analyze the efficacy and safety of liraglutide for the treatment of diabetes mellitus in comparison to other mono- and combination therapies. METHOD: PubMed (any date) and EMBASE (all years) search was conducted with liraglutide as a search term. Phase III clinical trials retrieved ... |
MED-706 | The aqueous extract of Hibiscus sabdariffa calices modulates the production of monocyte chemoattractant protein-1 in humans. | Diet supplementation and/or modulation is an important strategy to significantly improve human health. The search of plants as additional sources of bioactive phenolic compounds is relevant in this context. The aqueous extract of Hibiscus sabdariffa is rich in anthocyanins and other phenolic compounds including hydroxy... |
MED-707 | Uricosuric effect of Roselle (Hibiscus sabdariffa) in normal and renal-stone former subjects. | AIM OF THE STUDY: The Roselle (Hibiscus sabdariffa) was investigated for its uricosuric effect. MATERIALS AND METHODS: A human model with nine subjects with no history of renal stones (non-renal stone, NS) and nine with a history of renal stones (RS) was used in this study. A cup of tea made from 1.5 g of dry Roselle c... |
MED-708 | Inhibitory effect of marinades with hibiscus extract on formation of heterocyclic aromatic amines and sensory quality of fried beef patties. | Heterocyclic aromatic amines (HAA) are carcinogenic compounds found in the crust of fried meat. The objective was to examine the possibility of inhibiting HAA formation in fried beef patties by using marinades with different concentrations of hibiscus extract (Hibiscus sabdariffa) (0.2, 0.4, 0.6, 0.8 g/100g). After fry... |
MED-709 | Testicular effects of sub-chronic administration of Hibiscus sabdariffa calyx aqueous extract in rats. | The sub-chronic effect of Hibiscus sabdariffa (HS) calyx aqueous extract on the rat testes was investigated with a view to evaluate the pharmacological basis for the use of HS calyx extract as an aphrodisiac. Three test groups received different doses of 1.15, 2.30, and 4.60 g/kg based on the LD(50). The extracts were ... |
MED-711 | Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy). | Insulin resistance, obesity, hypertension, and dyslipidemia are strongly associated with metabolic syndrome (MeSy), which is considered to be a reversible clinical stage before its evolution to coronary heart disease and diabetes. Currently, the antihypertensive and hypolipidemic properties of aqueous Hibiscus sabdarif... |
MED-712 | Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne. | Hibiscus sabdariffa Linne is a traditional Chinese rose tea and has been effectively used in folk medicines for treatment of hypertension, inflammatory conditions. H. sabdariffa aqueous extracts (HSE) were prepared from the dried flowers of H. sabdariffa L., which are rich in phenolic acids, flavonoids and anthocyanins... |
MED-713 | Effects of water extract of Hibiscus sabdariffa, Linn (Malvaceae) 'Roselle' on excretion of a diclofenac formulation. | The effect of beverages prepared from the dried calyx of the flowers of Hibiscus sabdariffa on the excretion of diclofenac was investigated using a controlled study in healthy human volunteers. A high pressure liquid chromatographic method was used to analyse the 8 h urine samples collected after the administration of ... |
MED-714 | Towards prevention of vitamin D deficiency and beyond: knowledge gaps and research needs in vitamin D nutrition and public health. | The North American Institute of Medicine (IOM) recently published their report on dietary reference intakes (DRI) for Ca and vitamin D. The DRI committee's deliberations underpinning this most comprehensive report on vitamin D nutrition to date benefited hugely from a much expanded knowledge base in vitamin D over the ... |
MED-716 | VITAMIN D: A D-LIGHTFUL SOLUTION FOR HEALTH | Throughout evolution sunlight produced vitamin D in the skin has been critically important for health. Vitamin D, known as the sunshine vitamin, is actually a hormone. Once it is produced in the skin or ingested from the diet it is converted sequentially in the liver and kidneys to its biologically active form 1,25-dih... |
MED-717 | Fructose intake at current levels in the United States may cause gastrointestinal distress in normal adults. | OBJECTIVE: Fructose intake has increased considerably in the United States, primarily as a result of increased consumption of high-fructose corn syrup, fruits and juices, and crystalline fructose. The purpose was to determine how often fructose, in amounts commonly consumed, would result in malabsorption and/or symptom... |
MED-718 | The relation of passage of gas an abdominal bloating to colonic gas production. | OBJECTIVE: To determine the relation of gas passage and abdominal bloating to the production of gas in the colon. DESIGN: Randomized, double-blind, crossover study of gaseous symptoms during a 1-week period. SETTING: A Veterans Affairs medical center. PARTICIPANTS: 25 healthy medical center employees. INTERVENTION: Par... |
MED-719 | Flatulence--causes, relation to diet and remedies. | In addition to causing embarrassment and unease, flatulence is linked to a variety of symptoms, some of which may be distressing. This review describes the origins of intestinal gas, its composition and methods which have been developed for its analysis. Emphasis is placed upon the effects of legumes in the diet in pro... |
MED-720 | The effect of oral alpha-galactosidase on intestinal gas production and gas-related symptoms. | Bloating, abdominal distention, and flatulence represent very frequent complaints in functional disorders but their pathophysiology and treatment are largely unknown. Patients frequently associate these symptoms with excessive intestinal gas and the reduction of gas production may represent an effective strategy. The a... |
MED-721 | Bismuth therapy in gastrointestinal diseases. | Bismuth therapy has shown efficacy against two major gastrointestinal disorders: peptic ulcer disease and diarrhea. In peptic ulcer disease it is as effective as the H2-receptor antagonists, costs considerably less, and offers a lower rate of relapse. When Helicobacter pylori is implicated, bismuth acts as an antimicro... |
MED-722 | An understanding of excessive intestinal gas. | Complaints of "excessive gas" from patients are very common but are difficult, if not impossible, for the physician to document. This review addresses the pathophysiology and management of such complaints, looking at the sources and routes of elimination, excessive eructation, bloating, and distention. In addition, com... |
MED-723 | Effectiveness of devices purported to reduce flatus odor. | OBJECTIVE: A variety of charcoal-containing devices are purported to minimize problems with odoriferous rectal gas; however, the evidence supporting the efficacy of these products is virtually all anecdotal. We objectively evaluated the ability of these devices to adsorb two malodorous, sulfide gases (hydrogen sulfide ... |
MED-724 | Flatulence--causes, relation to diet and remedies. | In addition to causing embarrassment and unease, flatulence is linked to a variety of symptoms, some of which may be distressing. This review describes the origins of intestinal gas, its composition and methods which have been developed for its analysis. Emphasis is placed upon the effects of legumes in the diet in pro... |
MED-726 | Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama Study. | OBJECTIVE: The relationship between lipid profiles and Alzheimer disease (AD) pathology at the population level is unclear. We searched for evidence of AD-related pathologic risk of abnormal lipid metabolism. METHODS: This study included brain specimens from a series of 147 autopsies performed between 1998 and 2003 of ... |
MED-727 | Illuminating the 'black box'. A description of 4454 patient visits to 138 family physicians. | BACKGROUND: The content and context of family practice outpatient visits have never been fully described, leaving many aspects of family practice in a "black box," unseen by policymakers and understood only in isolation. This article describes community family practices, physicians, patients, and outpatient visits. MET... |
MED-728 | Barriers to providing nutrition counseling cited by physicians: a survey of primary care practitioners. | In a 1995 pivotal study, Kushner described the attitudes, practice behaviors, and barriers to the delivery of nutrition counseling by primary care physicians. This article recognized nutrition and dietary counseling as key components in the delivery of preventive services by primary care physicians. Kushner called for ... |
MED-729 | Transfer of spinal cord material to subsequent bovine carcasses at splitting. | During the slaughter process, cattle carcasses are split by sawing centrally down the vertebral column, resulting in contamination of each half with spinal cord material. Using a novel method based on a real-time PCR assay, we measured saw-mediated tissue transfer among carcasses. Up to 2.5% of the tissue recovered fro... |
MED-730 | Clinical herd health, farm management and antimicrobial resistance in Campylobacter coli on finishing pig farms in Switzerland. | The world-wide increase of antimicrobial resistance in micro-organisms complicates medical treatment of infected humans. We did a risk-factor analysis for the prevalence of antimicrobial resistant Campylobacter coli on 64 Swiss pig finishing farms. Between May and November 2001, 20 faecal samples per farm were collecte... |
MED-731 | Three rare cases of anthrax arising from the same source. | Anthrax is an acute bacterial infection caused by Bacillus anthracis. Humans become infected under natural conditions by contact with infected animals or contaminated animal products. About 95% of human anthrax is cutaneous and 5% respiratory. Gastrointestinal anthrax is very rare, and has been reported in less than 1%... |
MED-732 | Dissemination of central nervous system tissue during the slaughter of cattle in three Irish abattoirs. | Sponge samples were taken from the carcases, meat, personnel and surfaces involved in stunning, slaughter and dressing/boning activities at three abattoirs, and from retail beef products. The samples were examined for the presence of central nervous system (CNS)-specific proteins (syntaxin 1B and/or glial fibrillary ac... |
MED-733 | Amyloid arthropathy in chickens. | The present paper presents an overview of current knowledge of amyloid arthropathy in chickens, and covers the pathogenesis of amyloidosis in general and in birds, field cases reported, and the studies performed to assess the amyloidogenicity of various agents compared to that of Enterococcus faecalis. An animal model ... |
MED-734 | Susceptibility of the domestic duck (Anas platyrhynchos) to experimental infection with Toxoplasma gondii oocysts. | A total of 28 domestic ducks were divided into seven groups of four ducks. Six groups were inoculated per os with 10(1), 10(2), 10(3), 10(4), 10(5) and 10(5.7) oocysts Toxoplasma gondii oocysts (K21 strain, which is avirulent for mice), and the remaining group was used as a control. Antibodies to T. gondii were detecte... |
MED-735 | Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin. | BACKGROUND: Aspirin is valuable for preventing vascular events, but information about ulcer frequency is necessary to inform risk-benefit decisions in individual patients. AIM: To determine ulcer prevalence and incidence in a population representative of those given aspirin therapy and evaluate risk predictors. METHODS... |
MED-736 | Diverticular disease: Epidemiology and management | Diverticular disease of the colon is among the most prevalent conditions in western society and is among the leading reasons for outpatient visits and causes of hospitalization. While previously considered to be a disease primarily affecting the elderly, there is increasing incidence among individuals younger than 40 y... |
MED-743 | Herbal medicines, other than St. John's Wort, in the treatment of depression: a systematic review. | OBJECTIVE: To evaluate herbal medicines, other than St. John's wort, in the treatment of depression. DATA SOURCES/SEARCH METHODS: A computer-based search of Medline, Cinahl, AMED, ALT Health Watch, Psych Articles, Psych Info, Current Contents databases, Cochrane Controlled Trials Register, and Cochrane Database of Syst... |
MED-744 | Therapy with saffron and the goddess at Thera. | This paper presents a new interpretation of a unique Bronze Age (c. 3000-1100 BCE) Aegean wall painting in the building of Xeste 3 at Akrotiri,Thera. Crocus carturightianus and its active principle, saffron, are the primary subjects at Xeste 3. Several lines of evidence suggest that the meaning of these frescoes concer... |
MED-745 | The double-blind, randomized, placebo-controlled trial: gold standard or golden calf? | The double-blind randomized controlled trial (RCT) is accepted by medicine as objective scientific methodology that, when ideally performed, produces knowledge untainted by bias. The validity of the RCT rests not just on theoretical arguments, but also on the discrepancy between the RCT and less rigorous evidence (the ... |
MED-746 | Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study. | In this study, the effect of Crocus sativus (saffron) was studied on male erectile dysfunction (ED). Twenty male patients with ED were followed for ten days in which each morning they took a tablet containing 200mg of saffron. Patients underwent the nocturnal penile tumescence (NPT) test and the international index of ... |
MED-748 | Medical practice and social authority. | Questions of medical ethics are often treated as especially difficult casuistical problems or as difficult cases illustrative of paradoxes or advantages in global moral theories. I argue here, in opposition to such approaches, for the inseparability of questions of social history and social theory from any normative as... |
MED-749 | Current perception of nutrition education in U.S. medical schools. | Historically, physicians have perceived the quality of nutrition training during medical school as inadequate. A literature review suggests that this perception has not significantly changed since the 1950s. Many schools have worked to create clinical nutrition curricula for use during medical school. Interestingly, da... |
MED-751 | Dietary Fat and Cholesterol and Risk of Cardiovascular Disease in Older Adults: the Health ABC Study | BACKGROUND AND AIMS Although dietary fats and cholesterol have previously been associated with risk of cardiovascular disease (CVD) in middle aged populations, less is known among older adults. The purpose of this study was to determine the association between dietary fats, cholesterol, and eggs and CVD risk among comm... |
MED-752 | Phytoestrogens and their low dose combinations inhibit mRNA expression and activity of aromatase in human granulosa-luteal cells. | There is evidence that certain phytoestrogens inhibit aromatase, the enzyme that converts androgens to oestrogens. Kinetic studies in cell-free preparations show that they may inhibit aromatase by competitive binding to the enzyme, but there is a paucity of studies investigating longer-term effects of phytoestrogens on... |
MED-753 | Estrogen levels in nipple aspirate fluid and serum during a randomized soy trial | Background Based on the hypothesized protective effect, we examined the effect of soy foods on estrogens in nipple aspirate fluid (NAF) and serum, possible indicators of breast cancer risk. Methods In a cross-over design, we randomized 96 women who produced ≥10 μL NAF to a high- or low-soy diet for 6-months. During the... |
MED-754 | Effect of a dietary portfolio of cholesterol-lowering foods given at 2 levels of intensity of dietary advice on serum lipids in hyperlipidemia: a r... | CONTEXT: Combining foods with recognized cholesterol-lowering properties (dietary portfolio) has proven highly effective in lowering serum cholesterol under metabolically controlled conditions. OBJECTIVE: To assess the effect of a dietary portfolio administered at 2 levels of intensity on percentage change in low-densi... |
MED-756 | Diet-related telomere shortening and chromosome stability | Recent evidences have highlighted an influence of micronutrients in the maintenance of telomere length (TL). In order to explore whether diet-related telomere shortening had any physiological relevance and was accompanied by significant damage in the genome, in the present study, TL was assessed by terminal restriction... |
MED-757 | Turning back the clock: adopting a healthy lifestyle in middle age. | PURPOSE: To determine the frequency of adopting a healthy lifestyle (5 or more fruits and vegetables daily, regular exercise, BMI 18.5-29.9 kg/m2, no current smoking) in a middle-aged cohort, and determine the subsequent rates of cardiovascular disease (CVD) and mortality among those who adopt a healthy lifestyle. METH... |
MED-758 | Low-Risk Lifestyle Behaviors and All-Cause Mortality: Findings From the National Health and Nutrition Examination Survey III Mortality Study | Objectives. We examined the relationship between 4 low-risk behaviors—never smoked, healthy diet, adequate physical activity, and moderate alcohol consumption—and mortality in a representative sample of people in the United States. Methods. We used data from 16958 participants aged 17 years and older in the National He... |
MED-759 | Associations of dietary dark-green and deep-yellow vegetables and fruits with cervical intraepithelial neoplasia: modification by smoking. | Smoking has been positively and fruit and vegetable intake has been negatively associated with cervical cancer, the second most common cancer among women worldwide. However, a lower consumption of fruits and reduced serum carotenoids have been observed among smokers. It is not known whether the smoking effect on the ri... |
MED-760 | A High Antioxidant Spice Blend Attenuates Postprandial Insulin and Triglyceride Responses and Increases Some Plasma Measures of Antioxidant Activity in Healthy, Overweight Men | There is much interest in the potential of dietary antioxidants to attenuate in vivo oxidative stress, but little characterization of the time course of plasma effects exists. Culinary spices have demonstrated potent in vitro antioxidant properties. The objective of this study was to examine whether adding 14 g of a hi... |
MED-761 | The counseling practices of internists. | OBJECTIVES: To determine the counseling practices of a group of internists in the areas of smoking, exercise, and alcohol and seat belt use, and to determine the associations among physicians' personal health habits and their counseling practices. DESIGN: A random stratified sample of members and fellows of the America... |
MED-762 | The Ethiopian Field Epidemiology and Laboratory Training Program: strengthening public health systems and building human resource capacity. | The Ethiopian Field Epidemiology and Laboratory Training Program (EFELTP) is a comprehensive two-year competency-based training and service program designed to build sustainable public health expertise and capacity. Established in 2009, the program is a partnership between the Ethiopian Federal Ministry of Health, the ... |
MED-816 | The effect of obesity on polycystic ovary syndrome: a systematic review and meta-analysis. | While many women with polycystic ovary syndrome (PCOS) are overweight, obese or centrally obese, the effect of excess weight on the outcomes of PCOS is inconsistent. The review aimed to assess the effects of overweight, obesity and central obesity on the reproductive, metabolic and psychological features of PCOS. MEDLI... |
MED-818 | Role of maca (Lepidium meyenii) consumption on serum interleukin-6 levels and health status in populations living in the Peruvian central Andes over 4000 m of altitude | Lepidium meyenii (Maca) is a plant that grows at over 4000 meters above sea level in the central Peruvian Andes. The hypocotyls of this plant are traditionally consumed for their nutritional and medicinal properties. The aim of this study was to determine the health status based on a health related quality of life (HRQ... |
MED-819 | Effect of metformin compared with hypocaloric diet on serum C-reactive protein level and insulin resistance in obese and overweight women with poly... | AIM: The aim of the present study was to investigate the efficacy of Metformin compared with a hypocaloric diet on C-reactive protein (CRP) level and markers of insulin resistance in obese and overweight women with polycystic ovary syndrome (PCOS). MATERIAL AND METHODS: Forty women with body mass index ≥ 27 and PCOS we... |
MED-820 | The effect of marjoram (Origanum majorana) tea on the hormonal profile of women with polycystic ovary syndrome: a randomised controlled pilot study. | BACKGROUND: In traditional medicine, marjoram herb (Origanum majorana) is locally reputed for its ability to restore hormonal balance and to regulate the menstrual cycle. Therefore, this pilot study aimed to investigate the effects of marjoram tea on the hormonal profile of women with polycystic ovary syndrome (PCOS) i... |
MED-821 | Low glycemic index vegan or low-calorie weight loss diets for women with polycystic ovary syndrome: a randomized controlled feasibility study. | The aim of this randomized pilot was to assess the feasibility of a dietary intervention among women with polycystic ovary syndrome (PCOS) comparing a vegan to a low-calorie (low-cal) diet. Overweight (body mass index, 39.9 ± 6.1 kg/m(2)) women with PCOS (n = 18; age, 27.8 ± 4.5 years; 39% black) who were experiencing ... |
MED-822 | Clinical and biochemical characterization of women with polycystic ovary syndrome in North Rhine-Westphalia. | Polycystic ovary syndrome (PCOS), defined as the combination of oligoanovulation and hyperandrogenism, affects more than 5% of women of reproductive age. Insulin resistance and hyperinsulinemia appear to play an important role in its pathogenesis. Here, we will present a characterization of a PCOS cohort from North Rhi... |
MED-823 | Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines. | While lifestyle management is recommended as first-line treatment of polycystic ovary syndrome (PCOS), the optimal dietary composition is unclear. The aim of this study was to compare the effect of different diet compositions on anthropometric, reproductive, metabolic, and psychological outcomes in PCOS. A literature s... |
MED-824 | Dietary intervention versus metformin to improve the reproductive outcome in women with polycystic ovary syndrome. A prospective comparative study. | OBJECTIVE: To compare the clinical results and reproductive outcome in obese women with polycystic ovary syndrome (PCOS) following dietary intervention or treatment with metformin. METHODS: Forty-six patients with PCOS were studied prospectively in Prince Rashed Hospital, Irbid, Jordan, between January 2003 and April 2... |
MED-825 | Effects of increased dietary protein-to-carbohydrate ratios in women with polycystic ovary syndrome. | BACKGROUND: Some evidence has suggested that a diet with a higher ratio of protein to carbohydrates has metabolic advantages in the treatment of polycystic ovary syndrome (PCOS). OBJECTIVE: The objective of this study was to compare the effect of a high-protein (HP) diet to a standard-protein (SP) diet in women with PC... |
MED-826 | The polycystic ovary syndrome: a position statement from the European Society of Endocrinology. | Polycystic ovary syndrome (PCOS) is the most common ovarian disorder associated with androgen excess in women, which justifies the growing interest of endocrinologists. Great efforts have been made in the last 2 decades to define the syndrome. The presence of three different definitions for the diagnosis of PCOS reflec... |
MED-827 | Dietary habits in adolescent girls with polycystic ovarian syndrome. | The phenotype of polycystic ovarian syndrome (PCOS) is known to worsen with weight gain, increased ingestion of carbohydrates and a sedentary lifestyle. The purpose of this study was to assess the dietary habits in a group of adolescent girls with PCOS. Adolescents with PCOS were recruited and asked to complete a quest... |
MED-828 | Maca (L. meyenii) for improving sexual function: a systematic review | Background Maca (Lepidium meyenii) is an Andean plant of the brassica (mustard) family. Preparations from maca root have been reported to improve sexual function. The aim of this review was to assess the clinical evidence for or against the effectiveness of the maca plant as a treatment for sexual dysfunction. Methods ... |
MED-829 | Body fat composition and distribution in women with polycystic ovary syndrome. | OBJECTIVES: The aims of the present study were to compare the distribution and accumulation of body fat in women with polycystic ovary syndrome (PCOS) and healthy controls matched for age and body mass index (BMI), and to investigate the association between androgen levels, insulin resistance and fat distribution. MATE... |
MED-830 | Extraction, purification and antioxidant activities of the polysaccharides from maca (Lepidium meyenii). | Water-soluble polysaccharides were separated from maca (Lepidium meyenii) aqueous extract (MAE). The crude polysaccharides were deproteinized by Sevag method. During the preparation process of maca polysaccharides, amylase and glucoamylase effectively removed starch in maca polysaccharides. Four Lepidium meyenii polysa... |
MED-831 | DHEA, DHEAS and PCOS. | Approximately 20-30% of PCOS women demonstrate excess adrenal precursor androgen (APA) production, primarily using DHEAS as a marker of APA in general and more specifically DHEA, synthesis. The role of APA excess in determining or causing PCOS is unclear, although observations in patients with inherited APA excess (e.g... |
MED-832 | Structured exercise training programme versus hypocaloric hyperproteic diet in obese polycystic ovary syndrome patients with anovulatory infertilit... | BACKGROUND: Lifestyle modifications are successfully employed to treat obese and overweight women with polycystic ovary syndrome (PCOS). The aims of the current pilot study were (i) to compare the efficacy on reproductive functions of a structured exercise training (SET) programme with a diet programme in obese PCOS pa... |
MED-833 | Clinical, metabolic, and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome: a random... | The aim of this study was to evaluate the effects of metformin in addition to diet and exercise on endocrine and metabolic disturbances in women with polycystic ovary syndrome (PCOS) in a prospective, double-blind, randomized, placebo (PBO) control trial. Thirty women with insulin resistance and PCOS received lifestyle... |
MED-834 | Effect of lifestyle intervention on the reproductive endocrine profile in women with polycystic ovarian syndrome: a systematic review and meta-analysis | Polycystic ovarian syndrome (PCOS) affects 18–22% of women at reproductive age. We conducted a systematic review and meta-analysis evaluating the expected benefits of lifestyle (exercise plus diet) interventions on the reproductive endocrine profile in women with PCOS. Potential studies were identified by systematicall... |
MED-835 | Reducing bioavailable sex hormones through a comprehensive change in diet: the diet and androgens (DIANA) randomized trial. | High serum levels of testosterone and estradiol, the bioavailability of which may be increased by Western dietary habits, seem to be important risk factors for postmenopausal breast cancer. We hypothesized that an ad libitum diet low in animal fat and refined carbohydrates and rich in low-glycemic-index foods, monounsa... |
MED-836 | The optimal diet for women with polycystic ovary syndrome? | An optimal diet is one that not only prevents nutrient deficiencies by providing sufficient nutrients and energy for human growth and reproduction, but that also promotes health and longevity and reduces the risk of diet-related chronic diseases. The composition of the optimal diet for women with polycystic ovary syndr... |
MED-837 | A randomized trial of the effects of two types of short-term hypocaloric diets on weight loss in women with polycystic ovary syndrome. | OBJECTIVE: We performed this study as a pilot experiment to investigate the short term effects of two diets of varying composition on weight loss as the primary outcome in obese women with polycystic ovary syndrome (PCOS) seeking fertility. DESIGN: Randomized clinical trial. SETTING: Academic medical center. PATIENT(S)... |
MED-838 | Docosahexaenoic acid from a cultured microalga inhibits cell growth and induces apoptosis by upregulating Bax/Bcl-2 ratio in human breast carcinoma... | Docosahexaenoic acid (DHA) is an omega-3 fatty acid that comprises 22 carbons and 6 alternative double bonds in its hydrocarbon chain (22:6omega3). Previous studies have shown that DHA from fish oil controls the growth and development of different cancers; however, safety issues have been raised repeatedly about contam... |
MED-839 | Omega-3 fatty acids for nutrition and medicine: considering microalgae oil as a vegetarian source of EPA and DHA. | Long-chain EPA/DHA omega-3 fatty acid supplementation can be co-preventative and co-therapeutic. Current research suggests increasing accumulated long chain omega-3s for health benefits and as natural medicine in several major diseases. But many believe plant omega-3 sources are nutritionally and therapeutically equiva... |
MED-840 | Efficacy of home washing methods in controlling surface microbial contamination on fresh produce. | Much effort has been focused on sanitation of fresh produce at the commercial level; however, few options are available to the consumer. The purpose of this study was to determine the efficacy of different cleaning methods in reducing bacterial contamination on fresh produce in a home setting. Lettuce, broccoli, apples... |
MED-841 | Effect of dietary soy intake on breast cancer risk according to menopause and hormone receptor status. | BACKGROUND: Although high soy consumption may be associated with lower breast cancer risk in Asian populations, findings from epidemiological studies have been inconsistent. OBJECTIVE: We investigated the effects of soy intake on breast cancer risk among Korean women according to their menopausal and hormone receptor s... |
MED-842 | High Accumulation and Subcellular Distribution of Thallium in Green Cabbage (Brassica Oleracea L. Var. Capitata L.). | The accumulation of thallium (Tl) in brassicaceous crops is widely known, but both the uptake extents of Tl by the individual cultivars of green cabbage and the distribution of Tl in the tissues of green cabbage are not well understood. Five commonly available cultivars of green cabbage grown in the Tl-spiked pot-cultu... |
MED-843 | Treatment of vulvovaginal candidiasis with boric acid powder. | A double-blind comparison was made of the use of 14 daily intravaginal gelatin capsules containing 600 mg of boric acid powder versus the use of identical capsules containing 100,000 U nystatin diluted to volume with cornstarch for the treatment of vulvovaginal candidiasis albicans. Cure rates for boric acid were 92% a... |
MED-844 | Antifungal agents vs. boric acid for treating chronic mycotic vulvovaginitis. | Ninety-two women with chronic mycotic vaginal infections were followed with microscopic examination of the vaginal discharge during prolonged therapy with antifungal agents and boric acid. A microscopic picture unique to chronic mycotic vaginitis was observed, representing the cytologic reaction of the mucous membrane ... |
MED-845 | Boric acid inhibits embryonic histone deacetylases: a suggested mechanism to explain boric acid-related teratogenicity. | Histone deacetylases (HDAC) control gene expression by changing histonic as well as non histonic protein conformation. HDAC inhibitors (HDACi) are considered to be among the most promising drugs for epigenetic treatment for cancer. Recently a strict relationship between histone hyperacetylation in specific tissues of m... |
MED-846 | Antifungal mechanisms supporting boric acid therapy of Candida vaginitis. | BACKGROUND: Boric acid is a commonly cited treatment for recurrent and resistant yeast vaginitis, but data about the extent and mechanism of its antifungal activity are lacking. OBJECTIVES: The aim of this study was to use in vitro methods to understand the spectrum and mechanism of boric acid as a potential treatment ... |
MED-850 | Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis. | BACKGROUND & AIMS: Increasing evidence suggests that a low folate intake and impaired folate metabolism may be implicated in the development of gastrointestinal cancers. We conducted a systematic review with meta-analysis of epidemiologic studies evaluating the association of folate intake or genetic polymorphisms in 5... |
MED-851 | Chemoprevention in Barrett's oesophagus. | Barrett's oesophagus normally affects the distal oesophagus when metaplastic columnar lined epithelium replaces stratified squamous epithelium which predisposes to cancer development. This develops as a consequence of chronic gastroesophageal reflux (GORD). Those with Barrett's have a 40 fold increased risk of oesophag... |
MED-852 | Fiber intake and the risk of oral, pharyngeal and esophageal cancer. | The relation between various types of fiber and oral, pharyngeal and esophageal cancer was investigated using data from a case-control study conducted between 1992 and 1997 in Italy. Cases were 271 hospital patients with incident, histologically confirmed oral cancer, 327 with pharyngeal cancer and 304 with esophageal ... |
MED-853 | Hydrogen peroxide 3% exposures. | OBJECTIVE: To present a child who developed gastric ulcers and duodenal erosions after ingestion of hydrogen peroxide 3% and delineate the epidemiology, medical outcomes, and toxicity of exposures to this agent managed by a poison control center. METHODS: A retrospective chart review of exposures to hydrogen peroxide 3... |
MED-854 | Cerebral air gas embolism from concentrated hydrogen peroxide ingestion. | INTRODUCTION: Ingestion of a small amount of concentrated hydrogen peroxide can cause cerebral air gas embolism (CAGE). Hyperbaric oxygen therapy (HBOT) is the standard of care in the treatment of CAGE. We report a case of CAGE after accidental ingestion of 33%hydrogen peroxide treated with HBOT resulting in reversal o... |
MED-855 | Hydrogen peroxide poisoning. | Hydrogen peroxide is an oxidising agent that is used in a number of household products, including general-purpose disinfectants, chlorine-free bleaches, fabric stain removers, contact lens disinfectants and hair dyes, and it is a component of some tooth whitening products. In industry, the principal use of hydrogen per... |
MED-857 | Prospective studies of dietary alpha-linolenic acid intake and prostate cancer risk: a meta-analysis. | Individual-based studies that investigated the relation between dietary alpha-linolenic acid (ALA) intake and prostate cancer risk have shown inconsistent results. We carried out a meta-analysis of prospective studies to examine this association. We systematically searched studies published up to December 2008. Log rel... |
MED-859 | gamma-Irradiation dose: effects on baby-leaf spinach ascorbic acid, carotenoids, folate, alpha-tocopherol, and phylloquinone concentrations. | Ionizing radiation of fruits and vegetables, in the form of gamma rays or electron beams, is effective in overcoming quarantine barriers in trade and prolonging shelf life, but a void of information persists on ionizing radiation effects of vitamin profiles in individual foods. Baby-leaf spinach from commercial cultiva... |
MED-860 | Assessment of vitamin and carotenoid concentrations of emerging food products: edible microgreens. | Microgreens (seedlings of edible vegetables and herbs) have gained popularity as a new culinary trend over the past few years. Although small in size, microgreens can provide surprisingly intense flavors, vivid colors, and crisp textures and can be served as an edible garnish or a new salad ingredient. However, no scie... |
Dataset Card for BEIR Benchmark
Dataset Summary
BEIR is a heterogeneous benchmark that has been built from 18 diverse datasets representing 9 information retrieval tasks:
- Fact-checking: FEVER, Climate-FEVER, SciFact
- Question-Answering: NQ, HotpotQA, FiQA-2018
- Bio-Medical IR: TREC-COVID, BioASQ, NFCorpus
- News Retrieval: TREC-NEWS, Robust04
- Argument Retrieval: Touche-2020, ArguAna
- Duplicate Question Retrieval: Quora, CqaDupstack
- Citation-Prediction: SCIDOCS
- Tweet Retrieval: Signal-1M
- Entity Retrieval: DBPedia
All these datasets have been preprocessed and can be used for your experiments.
Supported Tasks and Leaderboards
The dataset supports a leaderboard that evaluates models against task-specific metrics such as F1 or EM, as well as their ability to retrieve supporting information from Wikipedia.
The current best performing models can be found here.
Languages
All tasks are in English (en).
Dataset Structure
All BEIR datasets must contain a corpus, queries and qrels (relevance judgments file). They must be in the following format:
corpusfile: a.jsonlfile (jsonlines) that contains a list of dictionaries, each with three fields_idwith unique document identifier,titlewith document title (optional) andtextwith document paragraph or passage. For example:{"_id": "doc1", "title": "Albert Einstein", "text": "Albert Einstein was a German-born...."}queriesfile: a.jsonlfile (jsonlines) that contains a list of dictionaries, each with two fields_idwith unique query identifier andtextwith query text. For example:{"_id": "q1", "text": "Who developed the mass-energy equivalence formula?"}qrelsfile: a.tsvfile (tab-seperated) that contains three columns, i.e. thequery-id,corpus-idandscorein this order. Keep 1st row as header. For example:q1 doc1 1
Data Instances
A high level example of any beir dataset:
corpus = {
"doc1" : {
"title": "Albert Einstein",
"text": "Albert Einstein was a German-born theoretical physicist. who developed the theory of relativity, \
one of the two pillars of modern physics (alongside quantum mechanics). His work is also known for \
its influence on the philosophy of science. He is best known to the general public for his mass–energy \
equivalence formula E = mc2, which has been dubbed 'the world's most famous equation'. He received the 1921 \
Nobel Prize in Physics 'for his services to theoretical physics, and especially for his discovery of the law \
of the photoelectric effect', a pivotal step in the development of quantum theory."
},
"doc2" : {
"title": "", # Keep title an empty string if not present
"text": "Wheat beer is a top-fermented beer which is brewed with a large proportion of wheat relative to the amount of \
malted barley. The two main varieties are German Weißbier and Belgian witbier; other types include Lambic (made\
with wild yeast), Berliner Weisse (a cloudy, sour beer), and Gose (a sour, salty beer)."
},
}
queries = {
"q1" : "Who developed the mass-energy equivalence formula?",
"q2" : "Which beer is brewed with a large proportion of wheat?"
}
qrels = {
"q1" : {"doc1": 1},
"q2" : {"doc2": 1},
}
Data Fields
Examples from all configurations have the following features:
Corpus
corpus: adictfeature representing the document title and passage text, made up of:_id: astringfeature representing the unique document idtitle: astringfeature, denoting the title of the document.text: astringfeature, denoting the text of the document.
Queries
queries: adictfeature representing the query, made up of:_id: astringfeature representing the unique query idtext: astringfeature, denoting the text of the query.
Qrels
qrels: adictfeature representing the query document relevance judgements, made up of:_id: astringfeature representing the query id_id: astringfeature, denoting the document id.score: aint32feature, denoting the relevance judgement between query and document.
Data Splits
| Dataset | Website | BEIR-Name | Type | Queries | Corpus | Rel D/Q | Down-load | md5 |
|---|---|---|---|---|---|---|---|---|
| MSMARCO | Homepage | msmarco |
traindevtest |
6,980 | 8.84M | 1.1 | Link | 444067daf65d982533ea17ebd59501e4 |
| TREC-COVID | Homepage | trec-covid |
test |
50 | 171K | 493.5 | Link | ce62140cb23feb9becf6270d0d1fe6d1 |
| NFCorpus | Homepage | nfcorpus |
traindevtest |
323 | 3.6K | 38.2 | Link | a89dba18a62ef92f7d323ec890a0d38d |
| BioASQ | Homepage | bioasq |
traintest |
500 | 14.91M | 8.05 | No | How to Reproduce? |
| NQ | Homepage | nq |
traintest |
3,452 | 2.68M | 1.2 | Link | d4d3d2e48787a744b6f6e691ff534307 |
| HotpotQA | Homepage | hotpotqa |
traindevtest |
7,405 | 5.23M | 2.0 | Link | f412724f78b0d91183a0e86805e16114 |
| FiQA-2018 | Homepage | fiqa |
traindevtest |
648 | 57K | 2.6 | Link | 17918ed23cd04fb15047f73e6c3bd9d9 |
| Signal-1M(RT) | Homepage | signal1m |
test |
97 | 2.86M | 19.6 | No | How to Reproduce? |
| TREC-NEWS | Homepage | trec-news |
test |
57 | 595K | 19.6 | No | How to Reproduce? |
| ArguAna | Homepage | arguana |
test |
1,406 | 8.67K | 1.0 | Link | 8ad3e3c2a5867cdced806d6503f29b99 |
| Touche-2020 | Homepage | webis-touche2020 |
test |
49 | 382K | 19.0 | Link | 46f650ba5a527fc69e0a6521c5a23563 |
| CQADupstack | Homepage | cqadupstack |
test |
13,145 | 457K | 1.4 | Link | 4e41456d7df8ee7760a7f866133bda78 |
| Quora | Homepage | quora |
devtest |
10,000 | 523K | 1.6 | Link | 18fb154900ba42a600f84b839c173167 |
| DBPedia | Homepage | dbpedia-entity |
devtest |
400 | 4.63M | 38.2 | Link | c2a39eb420a3164af735795df012ac2c |
| SCIDOCS | Homepage | scidocs |
test |
1,000 | 25K | 4.9 | Link | 38121350fc3a4d2f48850f6aff52e4a9 |
| FEVER | Homepage | fever |
traindevtest |
6,666 | 5.42M | 1.2 | Link | 5a818580227bfb4b35bb6fa46d9b6c03 |
| Climate-FEVER | Homepage | climate-fever |
test |
1,535 | 5.42M | 3.0 | Link | 8b66f0a9126c521bae2bde127b4dc99d |
| SciFact | Homepage | scifact |
traintest |
300 | 5K | 1.1 | Link | 5f7d1de60b170fc8027bb7898e2efca1 |
| Robust04 | Homepage | robust04 |
test |
249 | 528K | 69.9 | No | How to Reproduce? |
Dataset Creation
Curation Rationale
[Needs More Information]
Source Data
Initial Data Collection and Normalization
[Needs More Information]
Who are the source language producers?
[Needs More Information]
Annotations
Annotation process
[Needs More Information]
Who are the annotators?
[Needs More Information]
Personal and Sensitive Information
[Needs More Information]
Considerations for Using the Data
Social Impact of Dataset
[Needs More Information]
Discussion of Biases
[Needs More Information]
Other Known Limitations
[Needs More Information]
Additional Information
Dataset Curators
[Needs More Information]
Licensing Information
[Needs More Information]
Citation Information
Cite as:
@inproceedings{
thakur2021beir,
title={{BEIR}: A Heterogeneous Benchmark for Zero-shot Evaluation of Information Retrieval Models},
author={Nandan Thakur and Nils Reimers and Andreas R{\"u}ckl{\'e} and Abhishek Srivastava and Iryna Gurevych},
booktitle={Thirty-fifth Conference on Neural Information Processing Systems Datasets and Benchmarks Track (Round 2)},
year={2021},
url={https://openreview.net/forum?id=wCu6T5xFjeJ}
}
Contributions
Thanks to @Nthakur20 for adding this dataset.
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