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README.md
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- lifescience
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- Pharmaceutical
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- Pharma
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model-index:
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- name: Palmyra-Med-70B-32k
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results: []
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license_link: https://writer.com/legal/open-model-license/
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extra_gated_prompt: >-
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By clicking "Agree", you agree to the [License
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Agreement](https://writer.com/legal/open-model-license/)
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Policy](https://writer.com/legal/acceptable-use/).
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extra_gated_fields:
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Name: text
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Email: text
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messages:
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- role: system
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content: >-
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You are a highly knowledgeable and experienced expert in the healthcare
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- role: user
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content:
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output:
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text: >-
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Danzhi Xiaoyao San (DXS) exhibited significant antidepressant-like effects
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---
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```
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Contact
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-
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-
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- lifescience
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- Pharmaceutical
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- Pharma
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- Enterprise LLM
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- Enterprise
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- Enterprise ready
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model-index:
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- name: Palmyra-Med-70B-32k
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results: []
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license_link: https://writer.com/legal/open-model-license/
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extra_gated_prompt: >-
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By clicking "Agree", you agree to the [License
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Agreement](https://writer.com/legal/open-model-license/) and acknowledge
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Writer's [Privacy Policy](https://writer.com/legal/acceptable-use/).
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extra_gated_fields:
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Name: text
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Email: text
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messages:
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- role: system
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content: >-
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You are a highly knowledgeable and experienced expert in the healthcare
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and biomedical field, possessing extensive medical knowledge and practical
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expertise.
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- role: user
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content: >-
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Does danzhi Xiaoyao San ameliorate depressive-like behavior by shifting
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toward serotonin via the downregulation of hippocampal indoleamine
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2,3-dioxygenase?
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output:
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text: >-
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Danzhi Xiaoyao San (DXS) exhibited significant antidepressant-like effects
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in rats subjected to chronic unpredictable mild stress (CUMS), a commonly
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used model for inducing depressive-like behavior. The administration of
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DXS led to a notable reduction in the activity of indoleamine
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2,3-dioxygenase (IDO) in the hippocampus. This reduction in IDO activity
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is crucial because IDO is an enzyme that catalyzes the degradation of
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tryptophan into kynurenine (Kyn), thereby diverting tryptophan away from
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the serotonin (5-HT) synthesis pathway. By downregulating IDO, DXS
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effectively shifts the balance of tryptophan metabolism towards increased
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serotonin production, thereby enhancing the availability of serotonin.
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This shift in the Kyn/5-HT pathway favoring serotonin is likely a key
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mechanism underlying the antidepressant effects observed with DXS
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treatment. Enhanced serotonin levels in the hippocampus are associated
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with improved mood and reduction of depressive symptoms, suggesting that
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DXS could be a promising therapeutic agent for managing depression.
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---
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```
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Contact
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